No-op macros are line comments (starting with {{#!}} or {{;}}), {{#_}}, reader conditional (splicing or not) with no matching feature.
Furthermore once a no-op macro has been read regular whitespace are allowed anew.
Examples:
Namespaced map {{#foo{:bar :baz}}}
#:#_()#! bang bang
#?(:whatever 42); now a blank line
#?@(:default ())foo
{:bar :baz}
Tagged literal {{#inst "2017-04-24T09:11:29.878-00:00"}}
##_()#! bang bang
#?(:whatever 42); now a blank line
inst "2017-04-24T09:11:29.878-00:00"
Anonymous argument: {{#(do %1)}}
#(do %#_()#! bang bang
#?(:whatever 42); now a blank line
#?@(:default ())1)
In addition anonymous arguments implementation is leaky (any {{%n}} is accepted as long as {{n}} is (-2.0 -1.0] (mapping to {{%&}}) and [1.0 Infinity) and any representation can be used (bigdec or bigint or float or integers in any basis).
#(list %#_(first arg)1.00000001 %#_(secong arg)2r10 %#_(rest arg)-1.5)