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There are some GitHub repos that tried to achieve this, but there's no activity around them. There is also Hy, which seems to be inspired by Clojure, but for some reasons it doesn't want to be Clojure.

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https://github.com/clj-python/libpython-clj is very actively developed and allows the use of Python from Clojure. I'm not sure what the use case would be for "targeting Python" that's not satisfied by libpython-clj.