Comment made by: hiredman
it is tricky to express loop expression semantics in jvm byte code, so the compiler sort of punts, hoisting expression loops in to anonymous functions that are immediately invoked, closing over whatever is in scope that is required by the loop, this has some problems like those seen in CLJ-701, losing type data which the clojure compiler doesn't track across functions, the additional allocation of function objects (the jit may deal with that pretty well, I am not sure) etc.
where the world of clj-701 and this ticket collide is the patch on this ticket lifts the function body out as a loop expression, which without the patch in clj-701 will have the issues I listed above, but we already have those issues anywhere something that is difficult to express in bytecode as an expression (try and loop) is used as an expression, maybe it doesn't matter, or maybe clj-701 will get fixed in some way to alleviate those issues.
it seems like one feature people like from asserts is the ability to disable them in production (I have never actually seen someone do that with clojure), assert and :pre/:post have some ability to do that (it may only work at macroexpansion time, I don't recall) since the hoisting of the loop could impact performance it might be nice to have some mechanism to disable it (maybe using the same flag assert does?).